Asia Pacific Oncology and Cancer Conference December 04-05, 2019 Tokyo, Japan

Biography:

Tatiana Romantsova is currently working as a Professor at Department of Endocrinology in Sechenov University, Moscow. He is the author of 215 scientific articles.

Abstract:

As in many other developed nations, the problem of obesity is acute in Russia, where it’s prevalent in 24.1% of the population (28 million people). In Russia, Sibutramine (Reduxine) and a combination of Sibutramine and Metformin (ReduxineMet) are authorized to reduce weight in patients with obesity and type-2 diabetes mellitus or prediabetes. Since the administration of central-acting drugs as pharmacotherapy of obesity is the most pathogenetically justified treatment, the issue of safety of Sibutramine therapy is very important. In order to implement the principles of active monitoring of the efficacy and safety of Sibutramine in the current clinical practice and to develop an algorithm of it’s reasonable prescribing the observation studies “Vesna”, “Primavera” and “Aurora” were conducted in 2011-2017 under the auspices of Endocrinology Research Centre and the Russian Association of Endocrinologists. The programs were attended by 4,874 doctors of various specialties and 139.305 patients. In “Vesna” study it was shown that Sibutramine therapy is effective in weight loss, changing eating behavior and promotes positive changes in LDL, HDL, TG and fasting glucose.  In the “Primavera” study the body mass reducing dynamics during 3, 6, 12 months was 9.5±4.28 kg, 15.0±6.22 kg, 20.0±8.62 kg respectively. Moreover, it was shown that Reduxine therapy under the supervision of a physician was associated with decreased levels of systolic and diastolic blood pressure and had no effect on heart rate. Reduxine^® Met in “Aurora” study was being added to the diabetes therapy, that was chosen by the attending physician, prior to the patient's participation in the program. The average fasting plasma glucose and HbA1c reduction were 2±1.6 mmol/l and 1.2±1.1% respectively. Current studies show, that Sibutramine therapy of obesity according to approved indications is safe and effective for long-term treatment in regards to weight loss, regulation of lipemic index, glucose profile and quality of life.

Biography:

Dr. Jeffry Beta Tenggara has 8 years’ experience in treating oncology patients. He currently works in MRCCC Siloam Hospital Jakarta, a cancer hospital, as a medical oncologist and a member of Internal Medicine Department.In addition to his medical practice, he is a member of the Indonesian Society of Internal Medicine, Indonesian Society of Oncology, and Indonesian Medical Association.

Abstract:

Introduction: Docetaxel was frequently used to treat solid tumors, primarily breast cancer by disrupting microtubule function to inhibit cell division. Although this agent was known to cause myalgia, arthralgia and neuropathy, there are few reports since 2005 that published the myositis complication of this agent. We presented a case report of necrotizing fasciitis as a continuing myositis condition that happened after Docetaxel treatment.

Case Report: A 44 years old female diagnosed with stage-IIIB ductal invasive breast carcinoma (ER/PR+ HER-). She underwent chemotherapy with Docetaxel and Doxorubicin following the surgical treatment. After 6th chemotherapy cycle, the patient had pain at both thighs especially the left side. The symptom progressed until blisters seen on the skin and ulcer developed. Physical examination showed normal vital signs, ulceration at posterior left thigh with minimal purulent discharge, stiff and tender on palpation. Laboratory result showed elevated CRP and ESR with no elevated WBC and shifting of differential count. Doppler ultrasound showed soft tissue edema with no sign of DVT or thrombus, contrast MRI showed thickening and edema of the thigh muscle, enhancement of adductor brevis, semitendinosus, gluteus maximus and lateral vastus muscle, which consistent with myositis necroticans. PET- CT revealed necrotic irregular pattern on subcutaneous tissue including muscles at both posterior thigh compartment, with left domination. The result was different than previous PET- CT study which conducted before administration of Docetaxel. She was suspected with myositis complicated with secondary infection and planned to undergone surgical debridement. At intraoperative procedure, the surgeon found necrotic muscular tissue with no sign of primary infection. The tissues were sent for pathology examination. Pathology examination revealed necrotic tissues with gas inclusion, inflammatory cells (PMN and lymphocyte) and necrotic vascular tissues, these findings consistent with necrotizing fasciitis. In 1990s, reports of Docetaxel side effect began to revealed myopathy condition with unexplained pathophysiology. Documented cases of acute inflammatory myositis in patients treated with Docetaxel began to publish since 2005. Until 2015 there are less than 10 cases reported the myositis side effect of Docetaxel. The proposed theory linking this effect were direct myotoxicity, systemic leakage of protein in the interstitial space, increased cytokine levels (primarily IL-6, IL-8, IL-10), indirect muscle damage through hypocalcaemia and hyperthermia and accumulation of acid phosphatase in muscle lysosome. Although Docetaxel induced myositis was an exclusion diagnosis, this rare side effect must be considered to prevent further deteriorating condition.

Discussion: Myositis and necrotizing fasciitis is a rare side effect of Docetaxel that only few of reports documented since 2005. There are several proposed mechanisms linking this condition. Consideration and early recognition of this condition were needed to prevent further deterioration.

Biography:

Ami Makwana is Employee at Manipal hospital old airport road, hall, Bangalore as final year General surgery residency.

Abstract:

Introduction: Long term venous access is cumbersome in the pediatric age group due to thinner caliber veins, easy compromisation of venous integrity and less co-operative nature of children. Few studies are available that look at the use of chemoports in children and their complications.

Method: A retrospective analysis of children who underwent chemoport insertion from January 2008 to December 2017 was carried out.

Results: A total of 159 children (169 chemoports) were included in the study. The most common indication for chemoport insertion was acute lymphoblastic leukemia (52%). The mean chemoport days were 746±666 days. Among the 169 chemoports, 55% underwent chemoport removal as they completed the treatment. Chemoport hasn't been removed in 35% patients as 28% patients are still under treatment and 7% patients expired during the treatment. Sixteen (0.1 per 1000 chemoport days) patients had a premature removal of chemoport. The indications were port-related bloodstream infection (12 patients), port pocket infection (one patient), exposed chemoport (one patient) or blockage of the chemoport catheter (two patients). There were a total of 22 (0.15 per 1000 chemoport days) complications with port-related bloodstream infection (0.09 per 1000 chemoport days) being the commonest. Other complications include blockage, fracture, arrhythmias, avulsion, bleeding and decubitus over port, and port pocket infection.

Conclusion: The safe, reliable and low complication rate of chemoport helps us save more children from deadly illnesses. A standard technique of insertion, use of imaging modality, and well-trained nursing staff can bring down the complication rate to a negligible amount.

Biography:

Ms Rachel Xuan is a medical student in her final year of training from the University of New South Wales. She is currently posted at the Liverpool Hospital in Western Sydney in Australia and is rotating through her vascular surgery term.  She has a keen interest in diabetic foot complications and their surgical management.
 

Abstract:

The below knee amputation (BKA) is one of the oldest and most effective surgical procedures (1). It is often a critical component in the management of diabetic foot disease to obtain souce control in the setting of sepsis (2). Its technique has been refined from the first century to deal more effectively with haemorrhage, infection and pain. The introduction of ligatures, tourniquets, antibiotics and reonstructive flap techniques have all been beneficial technical adjuncts (3). Multiple factors contribute to good post-operative outcomes including, but not limited to, adequate blood supply, meticulous haemostasis, tension free closure, the appropriate selection of the amputation level and an atraumatic and efficient surgical technique with minimisation of electrocautery.

The operative positioning has classically been with the patient in a supine position with their knee extended. Although this has not changed, modern surgical tables and accessories can improve surgical outcomes. Herein, we discuss the use of a surgical 12” long footrest and a hip brace as an adjunct for BKA. They facilitate the sterile surgical prep of the leg, give easier access to the posterior flap and minimise the need for assistance during bony transections. The core principles of major limb amputation still apply for a good outcome and these adjuncts represent an incremental improvement to the classical setup for a BKA. We hope that this article will help the surgical community and doctors who perform this operation infrequently.

Biography:

Dr. Bala Usman Shamaki was born in May, 1969 at Kaltungo in Gombe State. He attended Nassarawa Pri. Sch. Kaltungo 1976-1978, Jama’are Centarl Pri. Sch. 1979-1980, Jekadafari Pri. Sch. Gombe, 1980-1982. He was among the pioneer students of the then Pilot Junior Secondary Sch. Gombe (1982-1985). after passing the JSSCE in 1985, he then proceeded to Govt. Sci. Sec. Sch. Darazo (1985-1987). He secured admission to remedial programme at the University of Maiduguri same year, and was admitted into Faculty of Veterinary Medicine, after successfully completing the remedial programme. He is currently an Associate Professor of Pharmacology, and the Pioneer Head of Department of the newly created Department of Veterinary Pharmacology and Toxicology, University of Maiduguri.

Abstract:

Squamous Cell Carcinoma (SCC) or skin cancer is the most common type of cancer in animals worldwide. There are claims of anticancer potentials of the wild Ganoderma sp., that is currently undergoing research, however, most of these researches involved in vitro studies methods using cell lines. Three sheep (Balami breed) were observed with cauliflower-like growths on various locations on their skins, and histopathological analysis from the skin biopsies revealed that it was squamous cell carcinoma. Using wild Ganoderma sp. based jelly at 6.7 mg/Ml. It was applied daily for two consecutive weeks on the specific growth areas on the treated sheep, while one of the sheep served as positive control with only the petrolatum jelly applied for the same period and the third sheep served as negative control and was not administered any topical treatment. Results from this study showed progressive regression of the tumorous growth in the treated sheep following topical application of the Ganoderma sp., based jelly treatment until completely cured after two weeks of topical application, while progressive growth of the tumor on the skin of both controls was observed within the same treatment periods. In conclusion, this study demonstrated that wild Ganoderma sp., based petrolatum paste preparation alone, can cure squamous cell carcinoma in sheep when compared to the control and may be a potential novel, ethno-therapy based anticancer agent for veterinary use.

Biography:

Abstract:

Biography:

Cintia do Couto Mascarenhas has completed her PhD at the age of 29 years from Faculty of Medicine - University of Campinas and postdoctoral studies from Catholic University of Brasília. She was a coordenator of clinical research center at Hematology and Hemoterapy Center at UNICAMP. She was a professor at Catholic University of Brasília since 2013 until 2019 july. Currently she is a CEO of 1Health Services a early startup, Ad hoc at Department of Science and Technology of the Brazilian Ministry of Health and also making her second undergraduate in Medicine.

Abstract:

Even though the screening protocols are eficient and widely recommended in reducing mortality for colon-rectum cancer the populations from different age groups can have distinct pathological and molecular profiles what can influence by screening and polyp resection, especially in older ages. A retrospective analysis was performed in tumors from stage IV CRC patients from a central pathology laboratory in Brazil that is a reference for mutational profiling countrywide. The study population was classified as pre-screening (PrSA; <45yo), screening(SA; 45-75yo) and post-screening age (PoSA; >75yo). Every tumor has been centrally reviewed by the pathologist. Groups were compared regarding clinicopathologic features and presence of RAS and BRAF mutations. Was included 1244 pts (164 PrSA, 919 SA and 161 PoSA) and have no significant difference among groups regarding sidedness (p= 0.68) and KRAS mutations (p=.0.97). Stage IV at diagnose (p =.001), presence of signet-ring cell component (p< .001) along with poorly differentiated tumors (p= .006) were most found on young patients, while BRAF and NRAS mutations where significantly more common among PosSA (table). PosSA and PreSA CRCs seem to present a distinct profile from SA populations, including molecular and pathologic differences what can impact the frequency of screening tests among different age groups.

Biography:

African Center of Excellence in Data Science, University of Rwanda, College of Business and Economics.

Abstract:

The most common known Non-communicable diseases (NCDs) are cardiovascular disease, cancer, diabetes and chronic respiratory diseases. World Health Organization had reported that 63% of total deaths, were due to NCDs, where diabetes count 3.5% and (2%) in 2008 and 2010 respectively [8]. Non-communicable diseases account for 36 percent of deaths in Rwanda, of which diabetes accounts 2%, in 2013 (, 2013). Researchers have worked on this problem using several approaches but in Rwanda the models to predict the future dynamics of diabetes do not exist yet. In this work, we predict the prevalence of type 2 diabetes among adult people. Metropolis-Hasting method was used to calculate the metropolis ratio. Data reported by World Health Organization in 2015 was used. Considering Suffering from diabetes, Overweight, Obesity, Dead and other subject as states of mathematical model, the transition matrix whose elements are probabilities is generated using Metropolis-Hasting sampling. The numerical results show that the prevalence of type 2 diabetes increases from 2.8% in 2015, 12.65% in 2020 to 22.59% in 2025. Therefore, this indicates the urgent need of prevention by Rwandan health decision makers who have to play their crucial role in encouraging physical activity, regular checkups and sensitization of the masses.

Biography:

Michael Retsky has completed his PhD in Experimental Physics from University of Chicago 1974. He is currently working as a Staff at Harvard TH Chan School of Public Health. He has 3 patents pending on methods to prevent late relapses. His over 100 papers in Physics and Oncology have been cited over 2500 times.

Abstract:

Most current cancer research aims to prevent cancer patients from dying from metastatic disease. To solve the problem upstream, i.e., to prevent relapses, with the unexpected observation of bimodal relapse patterns in breast and a number of other cancers. This was not consistent with the current cancer paradigm that has guided early detection and therapy for many years. Our multidisciplinary colleagues include surgeons, medical oncologists, anesthesiologists, biologists and physicists.

After much analysis including computer simulation and input from these medical and scientific specialists, we eventually came to the conclusion that surgery to remove the primary tumor produces systemic inflammation for about one week after the surgery. This systemic inflammation caused dormant single malignant cells and avascular micrometastases to exit from dormancy and result in relapses in the 3 years after surgery. Those relapses comprised the early peak.  We have determined that in breast cancer 50 to 80% of relapses (increasing with tumor size and positive nodes) are in the early peak so an effective method to prevent these relapses would be extremely important. It was then determined in a retrospective study that the common inexpensive perioperative NSAID ketorolac can prevent the early relapses. A second retrospective study strongly confirmed this result but a small prospective study found no advantage. The Pangrahy, ovarian and colon papers are very recent and not mentioned in the video to be presented at this conference.

Biography:

Catherine Maurice completed her residency training in Neurology at the University of Montreal in 2013. She then started a 2-year fellowship in neuro-oncology at the Pencer Brain Tumor Centre of Princess Margaret Hospital, Toronto, under the supervision of Dr Warren P. Mason. In 2015, University of Toronto Health Network recruited Dr. Catherine Maurice to work as an attending physician and clinical teacher. She developed a new neuro-oncology clinic focusing on the to assessment of neurologic complications resulting from systemic cancers and novel therapies. She also manages another clinic focused on primary brain tumors and is enrolled in the multidisciplinary Gamma-Knife Clinic of the Krembil Neuroscience Centre. Dr. Maurice is actively involved in teaching, trying to incorporate new technologies and virtual reality into medical education.

Abstract:

It is estimated that thirty to forty percent of all cancers can be prevented by lifestyle and dietary measures alone. The main goal is to potentially interfere with the development of precancerous tumors. Even healthy people have a certain number of latent cancerous cells in their tissues.   Spontaneous formation of small tumors happens frequently over a lifetime. However, the growth process is interrupted by our defense mechanisms. Those tumors remain microscopic and harmless, until they vanish. Free radicals, environment or diet-associated chemicals can severely damage DNA, leading ultimately to cancer. Certain fruits and vegetables can neutralize carcinogens, increase their excretion and inhibit tumorigenesis.  Food also plays a crucial role on the development and maintenance of the central and peripheral nervous system. This presentation aims to identify key concepts and interesting historical facts related to the impact of food in the field of Neuro-Oncology.